Naltrexone for 3 or 12 months did not reduce drinking in alcohol dependence
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چکیده
منابع مشابه
Naltrexone for 3 or 12 months did not reduce drinking in alcohol dependence.
In patients with alcohol dependence and a recent history of drinking to intoxication, is treatment with naltrexone for 3 or 12 months in addition to standardized psy-chosocial treatment more effective than placebo for reducing alcohol consumption? Randomized {allocation concealed*} †, blinded (participants and health care providers),* controlled trial with 52-week follow-up. 15 Veterans Affairs...
متن کاملNaltrexone for 3 or 12 months in addition to psychosocial counselling did not reduce drinking in alcohol dependence.
Patients 627 outpatients (mean age 49 y, 98% men) who had a diagnosis of alcohol dependence according to DSM-IV criteria, who had not drunk for >5 days, but who had a recent history of drinking to intoxication (heavy drinking at least twice during a 1 week period in the 30 days before screening, where heavy drinking was defined as >6 drinks for men and >4 drinks for women). Exclusion criteria i...
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Participants Mother-infant pairs were enrolled if the mother intended to breast feed, had no illnesses contraindicating breast feeding, and had given birth to a healthy, singleton infant who had a gestational age ≥ 37 weeks, birth weight ≥ 2500 g, and a 5 minute Apgar score ≥ 5. 17 046 mother-infant pairs were enrolled, and 16 471 (97%) completed follow up. 31 sites were included in the analysi...
متن کاملAcamprosate and naltrexone, individually or in combination, for the treatment of alcohol dependence
The findings of the COMBINE Study have recently been published (Anton et al 2006). The COMBINE Study is a major, multisite RCT of acamprosate and naltrexone in conjunction with behavioural treatment. As such this study has the potential to significantly influence treatment of alcohol dependence. This brief critical appraisal of the COMBINE Study has been prepared to assess its implications in t...
متن کاملGabapentin combined with naltrexone for the treatment of alcohol dependence.
OBJECTIVE Naltrexone, an efficacious medication for alcohol dependence, does not work for everyone. Symptoms such as insomnia and mood instability that are most evident during early abstinence might respond better to a different pharmacotherapy. Gabapentin may reduce these symptoms and help prevent early relapse. This clinical trial evaluated whether the combination of naltrexone and gabapentin...
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ژورنال
عنوان ژورنال: Evidence-Based Medicine
سال: 2002
ISSN: 1356-5524
DOI: 10.1136/ebm.7.4.125